Background If trials of therapeutic interventions are to serve society's interests, they must be of high methodological quality and must satisfy moral commitments to human subjects. The authors set out to develop a clinical - trials compendium in which standards for the ethical treatment of human subjects are integrated with standards for research methods. Methods The authors rank-ordered the world's nations and chose the 31 with >700 active trials as of 24 July 2008. Governmental and other authoritative entities of the (...) 31 countries were searched, and 1004 English-language documents containing ethical and/or methodological standards for clinical trials were identified. The authors extracted standards from 144 of those: 50 designated as ‘core’, 39 addressing trials of invasive procedures and a 5% sample of the remainder. As the integrating framework for the standards we developed a coherent taxonomy encompassing all elements of a trial's stages. Findings Review of the 144 documents yielded nearly 15 000 discrete standards. After duplicates were removed, 5903 substantive standards remained, distributed in the taxonomy as follows: initiation, 1401 standards, 8 divisions; design, 1869 standards, 16 divisions; conduct, 1473 standards, 8 divisions; analysing and reporting results, 997 standards, four divisions; and post-trial standards, 168 standards, 5 divisions. Conclusions The overwhelming number of source documents and standards uncovered in this study was not anticipated beforehand and confirms the extraordinary complexity of the clinical trials enterprise. This taxonomy of multinational ethical and methodological standards may help trialists and overseers improve the quality of clinical trials, particularly given the globalisation of clinical research. (shrink)

We extend results of Harizanov and Barker. For a relation R on a recursive structure /oA, we give conditions guaranteeing that the image of R in a recursive copy of /oA can be made to have arbitrary ∑α0 degree over Δα0. We give stronger conditions under which the image of R can be made ∑α0 degree as well. The degrees over Δα0 can be replaced by certain more general classes. We also generalize the Friedberg-Muchnik Theorem, giving conditions on a pair (...) of relations R and S under which the images of R and S can be made ∑α0 and independent over Δα0 in a recursive copy of /oA. (shrink)

Let be a recursive structure, and let R be a recursive relation on . Harizanov isolated a syntactical condition which is necessary and sufficient for to have recursive copies in which the image of R is r.e. of arbitrary r.e. degree. We had conjectured that a certain extension of Harizanov's syntactical condition would be necessary and sufficient for to have recursive copies in which the image of R is ∑α0 of arbitrary ∑α0 degree, but this is not the case. Here (...) we give examples illustrating some restrictions on the possible ∑α0 degrees. In these examples, the image of R cannot be ∑α0 of degree d unless d possesses an “α-table”. (shrink)

Originally published in 1954, on behalf of the National Institute of Economic and Social Research, this book presents a general review of British economic statistics in relation to the uses made of them for policy purposes. The text begins with an examination, in general terms, of the ways in which statistics can help in guiding or assessing policy, covering housing, coal, the development areas, agricultural price-fixing, the balance of external payments and the balance of the economy. The problems of statistical (...) application are then separately discussed under the headings of quality, presentation and availability, and organization. A full bibliography and reference table of principal British economic statistics are also included. This book will be of value to anyone with an interest in British economic history and statistics. (shrink)

Recently in this journal, R. Shaw-Smith suggested reading ‘citra Kal. Ian.’: ‘circa, implying that the consul died either before or after 1st January, will not do.’ Will the example of citra at Aug. 43.4, adduced by Shaw-Smith ] in support of the meaning ‘ before’?

It is argued that (1) the alleged violation of the auspices by both the Consuls of 249 B. C. did in fact occur and (2) resulted in separate prosecutions directed at each of them; (3) the name ‘Pullius’, reported for one of the plebeian Tribunes that prosecuted P. Claudius Pulcher, is probably authentic; (4) the cognomen of L. Iunius Pullus is not spun out the violation of the auspices attributed to him and his colleague; and (5) the cognomen ‘Pulcher’, first (...) born by the Consul of 249, may actually derive from his drowning of the Chickens. (shrink)